How To Get Triglycerides Down – High blood triglycerides (also known as hypertriglyceridemia or HTG) can increase your risk of metabolic syndrome, type 2 diabetes, and heart disease. The underlying causes of HTG result from an interaction between genetics and lifestyle factors.
Those of us with genetic risk variants in more than one of these pathways may be at greater risk for HTG than those with polymorphisms in one pathway. Similarly, dietary and lifestyle changes that target all three types can reduce risk. Please see Figure 1 for a summary of the association between these pathways and the major genes conferring polygenic HTG risk. People of East Asian and Native American descent are more likely to carry various risk factors in all three pathways, while people of African descent are less likely. This is consistent with the incidence of HTG in these populations (higher in East Asians, Native Americans, and Hispanics and less common in African Americans).
How To Get Triglycerides Down
1. Overproduction of triglycerides: Triglyceride (TG) in the blood can be obtained from many sources, including the food we eat, our adipose tissue, or it can be regenerated in our liver. When we eat excess energy (food), whether it’s in the form of carbohydrates, fat, or protein, the liver can turn it into fat for storage. However, not all foods are converted to TG equally. Simple carbohydrates (especially fructose found in soda and other sugary drinks and foods) are easily converted to TG (Chiavaroli L, 2015).
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2. Blockage of lipid transport: Triglycerides are packaged in VLDL lipoprotein particles in the liver and enter the blood. The enzyme LPL acts on TGs, breaking them down to their basic components so cells can take them up either for storage (fat) or energy use (muscle). LPL is modified in detail with positive and negative directions. The APOA5 gene increases, but the APOC3 gene suppresses LPL activity. Rare genetic abnormalities in this pathway increase the risk of HTG and are a significant contributor to cardiovascular disease (Brinton EA, 2016).
3. Inadequate use of triglycerides for fuel: TGs contain a lot of energy per unit and are therefore a selective form of energy storage. The excess food we eat is stored as fat in our adipose tissue, a genetically programmed process that underlies the “rich gene” principle. This principle dictates that our genes make it easier to burn fat when we have food available and need to rely on fuel stores. This is not so different from the common use of an outdoor propane tank for people who live in colder regions during the winter when energy needs are greatest. In situations of food shortage (or starvation), our body has systems that activate the breakdown of fat stores to provide the necessary energy.
Table 1. Proportion of people with genetic risk variants in genes affecting triglyceride levels by geographic origin. Data are from the 1000 Genomes Project. The following alleles are associated with higher triglyceride levels.
People with risk variants in their FADS1 genes may benefit from eating more foods that contain very long-chain PUFAs, such as fatty fish, egg yolks, chicken and organ meats. Eating enough very long-chain PUFA can reduce abnormal blood lipid levels and help prevent related diseases (Wijendran V, 2004 and Lu Y, 2010 and Nakayama K, 2010). In addition, moderate aerobic exercise is an excellent way to mobilize stored fat for energy.
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HealthWatch 360 can help analyze your diet for specific nutrients, such as omega-3 and omega-6 essential fatty acids and simple versus complex carbohydrates, among many others. If a genetic predisposition is suspected to be the main cause of abnormal lipid levels, we will offer genetic testing services through your doctor.
Chiavaroli L, de Souza RJ, Ha V, Cozma AI, Mirrahimi A, Wang DD, Yu M, Carleton AJ, Di Buono M, Jenkins AL, Leiter LA, Wolever TM, Beyene J, Kendall CW, Jenkins DJ, Sevenpiper JL.
Delezie J, Dumont S, Dardente H, Oudart H, Gréchez-Cassiau A, Klosen P, Teboul M, Delaunay F, Pevet P, Challet E.
Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, Warnes GR, Gómez Pérez FJ, Frazer KA, Elliott P, Scott J, Milos PM, Cox DR, Thompson JF.
How To Lower Triglycerides
Lai CQ, Corella D, Demissie S, Cupples LA, Adiconis X, Zhu Y, Parnell LD, Tucker KL, Ordovas JM.
Dietary n-6 fatty acid intake modulates the effect of the apolipoprotein A5 gene on fasting plasma triglycerides, residual lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study.
Dietary n-3 and n-6 polyunsaturated fatty acids are associated with FADS1 genetic variation affecting total and HDL cholesterol in the Doetinchem cohort study.
A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar and lifestyle-distinct Asian ethnic groups.
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Pollex RL, Ban MR, Young TK, Bjerregaard P, Anand SS, Yusuf S, Zinman B, Harris SB, Hanley AJ, Connelly PW, Huff MW, Hegele RA.
Sarwar N, Sandhu MS, Ricketts SL, Butterworth AS, Di Angelantonio E, Boekholdt SM, Ouwehand W, Watkins H, Samani NJ, Saleheen D, Lawlor D, Reilly MP, Hingorani AD, Talmud PJ, Danesh J.
Wang J, Ban MR, Zou GY, Cao H, Lin T, Kennedy BA, Anand S, Yusuf S, Huff MW, Pollex RL, Hegele RA.
The information provided on the GB HealthWatch website is for informational purposes only. It is not a substitute for professional medical advice, diagnosis or treatment. Never put off or delay seeking treatment because of something you read on the GB HealthWatch website. GB HealthWatch encourages you to consult a medical professional for a diagnosis and answers to your personal health questions. If you think you may have a medical emergency, call your doctor or 911 immediately. It was 2:48 pm and I was sitting with my diabetologist who, as expected, was not happy about my high HbA1C. But what worried him a bit more was my very high triglycerides. He said triglycerides should be under 150mg/dl and at the time my reports were 1202mg/dl. He said: “You really need to improve your lifestyle to normalize HbA1C, high triglycerides and body weight, otherwise it will affect my health more.”
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I thought, “I knew triglycerides were related to cholesterol and therefore related to my heart, but what else should I know?” The diabetologist gave me the necessary medical help, prescribed medicine and referred me to a dietician.
The next day, I took some time out of my busy schedule and consulted a nutritionist. She asked me about my daily routine. I said I don’t have a set schedule because I’m busy with clients and meetings. Sometimes I skip lunch and sometimes I eat out. Also, no physical activity. She said that my lifestyle is one of the reasons why I have high body weight, sugar and triglycerides. She recommended me a balanced diet and asked me to start walking in the morning.
It has been 5 months since then and I am following the advice of my doctor and nutritionist. Now I feel more energetic, confident and happy all the time. My weight, blood sugar and triglycerides have improved significantly. All this made me realize that it is important for everyone to be aware of their health condition, consult the right Doctor and make sure that he follows his recommendations religiously.
After reading the story above, you may have some questions about your health and high triglycerides. Don’t worry, we’ve got you covered!
Simple Ways To Lower Your Triglyceride Levels
Triglycerides (TG) are a type of fat that is produced in our bodies or produced in our bodies mainly from the foods we eat such as fats, oils, fats, etc. and sometimes from the extra calories we consume. Triglycerides are stored in fat cells and are the main component of body fat in humans. Hormones release these triglycerides when the body needs energy to function.
High levels of triglycerides in the blood are medically known as hypertriglyceridemia. Triglyceride levels are usually measured during a blood test, ie a lipid profile test.
People in this category should be more careful about their health to prevent high triglycerides and the risk of other heart diseases.
Now we know what triglycerides are and who is more prone to them. Let’s discuss – what causes high triglyceride levels?.
Ester Bonding (a Level Biology)
There are many reasons why blood TG levels are high. Here are some common causes of high TG levels that you may already know about:
4. Lack of physical activity – Exercising has many benefits and one of them is increasing the level of triglycerides in our blood. Exercise will make us feel good while burning excess fat cells and boosting metabolism.
5. Excessive consumption of alcohol- Alcohol is known to have many negative effects on our body. When we drink alcohol, it is broken down into simpler forms and some of them are converted
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